Save

Support us to Promote Research!

icon-donate-rouge

Follow Valdig

icon-twitter__icon-facebook__icon-google

Members zone

Research projects

.

PNH and Splanchnic Vein Thrombosis

Data from patients with PNH and splanchnic vein thrombosis from the European vascular disease interest group VALDIG and French vascular network will be retrospectively reviewed. Only patients with a diagnosis of splanchnic vein thrombosis made between 2000 and 2016 will be included.

Study-documentation

Members only

_

We will compare the evolution of thrombosis in patients who received a “curative” treatment for PNH, including eculizumab and bone marrow transplantation, to patients who did not receive one of these 2 types of treatments, either because it was not available or when the patient did not have HLA compatible donor.

VALDIG Database and Registry

Vascular diseases of the liver are a heterogeneous group of rare and if untreated fatal disorders that include portal vein thrombosis, Budd-Chiari syndrome, non-cirrhotic portal hypertension, sinusoidal obstruction syndrome, hereditary hemorrhagic teleangiectasia and others.

Current knowledge about patients suffering from these disorders is insufficient and no biological samples are available to study the mechanisms of these diseases and the effects of treatments.

Therefore, with the support of a grant from EASL, we are running this cohort study by including and following up patients on the platform redcap.ctu.unibe.ch. If you are member of VALDIG you can request a password and username (contact andrea.degottardi@insel.ch) to participate to this study by including patients from your center into the database (a complete set of data) or into the registry (a limited set of data).

Study-documentation

Members only

Save

AIMS:

- To characterize the population with vascular liver disease in Switzerland by defining history, outcome and risk factors.

- To build a bio-bank with blood from these patients.

INCPH and Pregnancy

Idiopathic portal hypertension, non-cirrhotic portal fibrosis and idiopathic non-cirrhotic portal hypertension (INCPH) indicate the same clinical entity. This includes the histological diagnosis of obliterative portal venopathy, hepatoportal sclerosis, nodular regenerative hyperplasia and incomplete septal cirrhosis. These terms, thereafter referred to as INCPH, designate a heterogeneous group of liver diseases causing portal hypertension and characterized by the absence of cirrhotic modification of the liver parenchyma and the patency of the portal and hepatic veins.

Study-documentation
Members only

AIMS:

To retrospectively assess the fetal and maternal outcome of women who became pregnant after INCPH had been recognized and treated.

Liver Disease after Fontan Surgery

The Fontan procedure refers to a set of cardiac surgery techniques used to treat univentricular congenital heart disease. In this setting, liver disease results from hypoxia secondary to low cardiac output and hepatic venous outflow obstruction.

Study-documentation
Members only

AIMS:

To assess the severity of liver damage, the presence of protein losing enteropathy and their clinical impact in patients with Fontan surgery.

Abernethy malformation

Congenital extrahepatic portosystemic shunts (Abernethy malformation): European Survey of current management strategies and clinical outcome.

Abernethy malformation is a rare disease with few reported cases in the literature and therefore its natural history is not well known.

Knowing the clinical onset and the outcome of this condition by gathering a large number of patients in a multicentric European study will allow to better know the natural history, long-term outcome and results of the treatments applied so far.

Study-documentation

Members only

AIMS:

  1. Describing natural history in Abernethy malformation.
  2. Propose new follow up and therapeutic strategies according with the observed natural history, long-term outcome and results of the treatment strategies applied so far.

This study will follow “Good Clinical Practice”(GCP) standards and Declaration of Helsinki (1964) and Edinburgh revision (2000). All clinical data and clinical files of every patient will be managed confidentially and case treatment will be with a codification.

DOACsimg_closed

European Survey on the use of direct oral anticoagulants (DOACs) in patients with vascular liver disease and/or cirrhosis.

Publication: www.ncbi.nlm.nih.gov/pubmed/27778440

Study-documentation

Members only

Contact

Prof. Dr. A. De Gottardi
Inselspital, Universitätsspital Bern Universitätsklinik für Viszerale Chirurgie und Medizin,
Bereich Hepatologie
CH - 3010 Bern

Endorsed by

logo-EASL