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Research projects

Medically assisted reproduction in women with vascular liver diseases

This retrospective study tries to determine the safety and efficacy of medically assisted reproduction in women with known Budd-Chiari syndrome, portal vein thrombosis or porto-sinusoidal vascular disease. Women with vascular liver diseases who underwent medically assisted reproduction between 2000 and 2018 will be included. This includes controlled pharmacologic stimulation of ovarian follicles, paired or not with assisted reproduction technologies. Vascular liver disease should be diagnosed prior to medically assisted reproduction.

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AIMS:

The aim of this retrospective study is thus to determine the safety and efficacy of medically assisted reproduction in women with known Budd-Chiari syndrome, portal vein thrombosis or vascular porto-sinusoidal disease.

PNH and Splanchnic Vein Thrombosis

Data from patients with PNH and splanchnic vein thrombosis from the European vascular disease interest group VALDIG and French vascular network will be retrospectively reviewed. Only patients with a diagnosis of splanchnic vein thrombosis made between 2000 and 2016 will be included.

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AIMS:
We will compare the evolution of thrombosis in patients who received a “curative” treatment for PNH, including eculizumab and bone marrow transplantation, to patients who did not receive one of these 2 types of treatments, either because it was not available or when the patient did not have HLA compatible donor.

VALDIG Database and Registry

Vascular diseases of the liver are a heterogeneous group of rare and if untreated fatal disorders that include portal vein thrombosis, Budd-Chiari syndrome, non-cirrhotic portal hypertension, sinusoidal obstruction syndrome, hereditary hemorrhagic teleangiectasia and others.

Current knowledge about patients suffering from these disorders is insufficient and no biological samples are available to study the mechanisms of these diseases and the effects of treatments.

Therefore, with the support of a grant from EASL, we are running this cohort study by including and following up patients on the platform redcap.ctu.unibe.ch. If you are member of VALDIG you can request a password and username (contact andrea.degottardi@insel.ch) to participate to this study by including patients from your center into the database (a complete set of data) or into the registry (a limited set of data).Save

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AIMS:

  • To characterize the population with vascular liver disease in Switzerland by defining history, outcome and risk factors.
  • To build a bio-bank with blood from these patients.

For more information and the study descriptions see here

Contact

Prof. Dr. A. De Gottardi
Inselspital, Universitätsspital Bern Universitätsklinik für Viszerale Chirurgie und Medizin,
Bereich Hepatologie
CH - 3010 Bern

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